Invention Grant
- Patent Title: Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
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Application No.: US16061815Application Date: 2016-12-15
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Publication No.: US10519147B2Publication Date: 2019-12-31
- Inventor: Thomas J. Greshock , James Mulhearn , Liangqin Guo , Ting Zhang , Deping Wang , Ronald M. Kim , Mark E. Layton , Michael J. Kelly, III , Rajan Anand , Philippe Nantermet , Tianying Jian , Anthony J. Roecker , Walter Won , Gang Zhou
- Applicant: Merck Sharp & Dohme Corp. , Thomas J. Greshock , James Mulhearn , Liangqin Guo , Ting Zhang , Deping Wang , Ronald M. Kim , Mark E. Layton , Michael J. Kelly, III , Rajan Anand , Philippe Nantermet , Tianying Jian , Anthony J. Roecker , Walter Won , Gang Zhou
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Patricia A. Shatynski; John C. Todaro
- International Application: PCT/US2016/066765 WO 20161215
- International Announcement: WO2017/106409 WO 20170622
- Main IPC: C07D417/12
- IPC: C07D417/12 ; A61K45/06 ; C07D277/52 ; C07D285/135 ; A61P25/02 ; A61P25/04 ; A61P11/14 ; A61P17/04
Abstract:
Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.
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