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公开(公告)号：US20220242847A1
公开(公告)日：2022-08-04
申请号：US17611448
申请日：2020-05-18
申请人： Antonella CONVERSO , Abdellatif EL MARROUNI , Ashley FORSTER , Jessica L. FRIE , David N. HUNTER , Cheng WANG , Deping WANG , Merck Sharp & Dohme Corp.
发明人： Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Cheng Wang , Deping Wang
IPC分类号： C07D401/06 , C07D401/14 , A61K45/06 , A61K31/506 , A61P31/18
摘要： The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
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2.发明申请公开(公告)号：US20180362518A1
公开(公告)日：2018-12-20
申请号：US16061815
申请日：2016-12-15
申请人： Thomas J. GRESHOCK , James MULHEARN , Liangqin GUO , Ting ZHANG , Deping WANG , Ronald M. KIM , Mark E. LAYTON , Michael J. KELLY, III , Rajan ANAND , Tianying JIAN , Philippe NANTERMET , Anthony J. ROECKER , Walter WON , Gang ZHOU , Merck Sharp & Dohme Corp.
发明人： Thomas J. Greshock , James Mulhearn , Liangqin Guo , Ting Zhang , Deping Wang , Ronald M. Kim , Mark E. Layton , Michael J. Kelly, III , Rajan Anand , Philippe Nantermet , Tianying Jian , Anthony J. Roecker , Walter Won , Gang Zhou
IPC分类号： C07D417/12 , C07D285/135 , C07D277/52 , A61P11/14 , A61P17/04 , A61P25/04 , A61P25/02
CPC分类号： C07D417/12 , A61K45/06 , A61P11/14 , A61P17/04 , A61P25/02 , A61P25/04 , C07D277/52 , C07D285/135
摘要： Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Na 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.
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公开(公告)号：US09273028B2
公开(公告)日：2016-03-01
申请号：US13882449
申请日：2011-10-28
申请人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
发明人： Brian T. Hopkins , Daniel Scott , Patrick Conlon , Tracy J. Jenkins , Noel Powell , Bing Guan , Julio H. Cuervo , Deping Wang , Art Taveras
IPC分类号： A01N43/00 , A61K31/00 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D487/04 , C07D519/00 , C07D473/34 , C07D513/04
CPC分类号： A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20120157443A1
公开(公告)日：2012-06-21
申请号：US13393192
申请日：2010-09-03
申请人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
发明人： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC分类号： A61K31/553 , C07D487/04 , A61K31/519 , C07D401/04 , A61K31/506 , C07D473/34 , A61K31/52 , C07D417/14 , C07D413/12 , C07D401/14 , A61K31/55 , A61P37/06 , A61P29/00 , A61P35/00 , A61P35/02 , C12N9/99
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译： 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20090118502A1
公开(公告)日：2009-05-07
申请号：US12275941
申请日：2008-11-21
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Josseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Josseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： C07D413/02 , C07D401/02
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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公开(公告)号：US20060264426A1
公开(公告)日：2006-11-23
申请号：US11486769
申请日：2006-07-14
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay Farmer , Joel Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega Oyelere , Joseph Salvino , Dane Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/52 , A61K31/498 , A61K31/496 , A61K31/454 , A61K31/4709 , A61K31/422 , C07D473/02 , C07D417/02 , C07D403/02
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
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7.发明授权公开(公告)号：US07091196B2
公开(公告)日：2006-08-15
申请号：US10671326
申请日：2003-09-25
申请人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
发明人： Deping Wang , Joyce A. Sutcliffe , Adegboyega K. Oyelere , Timothy S. McConnell , Joseph A. Ippolito , John N. Abelson , Dane M. Springer , Joseph M. Salvino , Rongliang Lou , Joel A. Goldberg , Jay J. Farmer , Erin M. Duffy , Ashoke Bhattacharjee
IPC分类号： C07D267/00 , C07D413/14 , A61K31/5377
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要： The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents, and/or prokinetic (gastrointestinal modulatory) agents, having the formula: or pharmaceutically acceptable salts, esters, or prodrugs thereof.
摘要翻译： 本发明提供了可用作抗感染剂和/或抗增殖剂的化合物家族，例如化学治疗剂，抗真菌剂，抗细菌剂，抗寄生虫剂，抗病毒剂和/或 具有下式的抗炎剂和/或促动力（胃肠调节剂）或其药学上可接受的盐，酯或前药。
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公开(公告)号：US20180134712A1
公开(公告)日：2018-05-17
申请号：US15574411
申请日：2016-05-24
申请人： Dong-Ming SHEN , Michael P. DWYER , Christopher J. SINZ , Deping WANG , Shawn J. STACHEL , Daniel V. PAONE , Ashley FORSTER , Richard BERGER , William D. SHIPE , Yili CHEN , Yimin QIAN , Shimin XU , Chunmei HU , Jianmin FU , Zhigang GUO , Haitang LI , Yingjian BO , Merck Sharp & Dohme Corp. , MSD R & D (China) Co., LTD.
发明人： Dong-Ming Shen , Michael P. Dwyer , Christopher J. Sinz , Deping Wang , Shawn J. Stachel , Daniel V. Paone , Ashley Forster , Richard Berger , Yilli Chen , Yimin Qian , Shimin Xu , Chunmel Hu , William D. Shipe , Jianmin Fu , Zhigang Guo , HAITANG LI , Yingjian Bo
CPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28
摘要： The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypo-function or basal ganglia dysfunction.
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9.发明申请公开(公告)号：US20100234591A1
公开(公告)日：2010-09-16
申请号：US12767380
申请日：2010-04-26
申请人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Rongliang Lou , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： C07D417/10 , C07D413/10
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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10.发明授权公开(公告)号：US07148219B2
公开(公告)日：2006-12-12
申请号：US11118808
申请日：2005-04-29
申请人： Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
发明人： Rongliang Lou , Jiacheng Zhou , Ashoke Bhattacharjee , Shili Chen , Yi Chen , Jay J. Farmer , Joel A. Goldberg , Roger Hanselmann , Alia Orbin , Adegboyega K. Oyelere , Joseph M. Salvino , Dane M. Springer , Jennifer Tran , Deping Wang , Yusheng Wu
IPC分类号： A61K31/513 , A61K31/496 , A61K31/506 , A61K31/4439 , A61K31/454
CPC分类号： C07D487/04 , C07D263/20 , C07D263/24 , C07D263/26 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D473/00 , C07D473/34
摘要： The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.
摘要翻译： 本发明一般涉及抗感染，抗增殖，抗炎和促动力的领域。 更具体地，本发明涉及具有联芳基部分和至少一个可用作这种试剂的杂环部分的化合物族。
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