A cable fixation device (100, 200, 300, 400) includes a base (102, 202) with fastener holes (104), an upright (110, 208) projecting from the base and including a fixation projection (126, 212, 316, 318) having a reduced dimensional portion (128, 214, 324) for receiving a cable tie (152, 222, 326). Protrusions (130, 218, 320) are provided for engaging the cable jacket. Variations on the cable fixation device include a fixation element (130, 218, 320) which can slide and/or rotate about a vertical rod; a plate element (304) which includes a plurality of fixation projections extending between two rods; and a plurality of uprights (208) integrally formed with the base and including forwardly and rearwardly projecting projections. The base (102, 202) and the fixation projections (126, 212, 316, 318) can be made from molded plastic.