- 专利标题: Isobaric mass labels
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申请号: US15318247申请日: 2015-06-12
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公开(公告)号: US10527629B2公开(公告)日: 2020-01-07
- 发明人: Andrew Hugin Thompson , Stefan Kienle , Karsten Kuhn , Nikolai Woellmer
- 申请人: Electrophoretics Limited
- 申请人地址: GB Surrey
- 专利权人: ELECTROPHORETICS LIMITED
- 当前专利权人: ELECTROPHORETICS LIMITED
- 当前专利权人地址: GB Surrey
- 代理机构: Arent Fox LLP
- 优先权: GB1410523.3 20140612
- 国际申请: PCT/EP2015/063224 WO 20150612
- 国际公布: WO2015/189413 WO 20151217
- 主分类号: G01N33/00
- IPC分类号: G01N33/00 ; G01N33/68 ; C12Q1/6872 ; C07B59/00 ; C07K5/02
摘要:
The present invention relates to a set of two or more mass labels. Each mass label comprises: X-L-M-Re; X is a reporter moiety having exact mass; L is a bond cleavable by collision in a mass spectrometer; M is a mass modifier; Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte. Each mass label in the set has the same integer mass; wherein the set comprises two or more subsets of mass labels, each subset comprising one or more mass labels; wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets; each mass label is distinguishable by mass spectrometry.
公开/授权文献
- US20170146549A1 ISOBARIC MASS LABELS 公开/授权日:2017-05-25