- 专利标题： Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics
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申请号： US15508059申请日： 2015-09-10
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公开(公告)号： US10533056B2公开(公告)日： 2020-01-14
- 发明人: Bin Liu , Yang Su , Scott Bidlingmaier , Christopher R. Behrens , Namkyung Lee
- 申请人： The Regents of The University of California
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： Weaver Austin Villeneuve & Sampson LLP
- 代理商 Tom Hunter
- 国际申请： PCT/US2015/049492 WO 20150910
- 国际公布： WO2016/040683 WO 20160317
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; G01N33/574 ; C07K16/30 ; A61K47/68 ; A61K39/00
摘要：
In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.
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