公开(公告)号：US20190276553A1

公开(公告)日：2019-09-12

申请号：US16348135

申请日：2017-11-10

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  A61K47/68

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US20230383005A1

公开(公告)日：2023-11-30

申请号：US17815514

申请日：2022-07-27

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K16/2896 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6813 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/3069 ,  C12Q1/6886 ,  A61K47/6803 ,  C07K16/00 ,  G01N33/57492 ,  A61K2039/55

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US11434301B2

公开(公告)日：2022-09-06

申请号：US16348135

申请日：2017-11-10

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574 ,  A61K39/00

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US10533056B2

公开(公告)日：2020-01-14

申请号：US15508059

申请日：2015-09-10

申请人： The Regents of The University of California

发明人： Bin Liu ,  Yang Su ,  Scott Bidlingmaier ,  Christopher R. Behrens ,  Namkyung Lee

IPC分类号： C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K47/68 ,  A61K39/00

摘要： In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.

公开(公告)号：US20170362330A1

公开(公告)日：2017-12-21

申请号：US15508059

申请日：2015-09-10

申请人： The Regents of The University of California

发明人： BIN LIU ,  Yang Su ,  Scott Bidlingmaier ,  Christopher R. Behrens ,  Namkyung Lee

IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/2896 ,  A61K31/7088 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6869 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/77 ,  G01N33/57492 ,  G01N2333/70596 ,  Y02A50/466

摘要： In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.