Fluid property modeling that employs a model that characterizes asphaltene concentration gradients is integrated into a reservoir modeling and simulation framework to allow for reservoir compartmentalization (the presence or absence of flow barrier in the reservoir) to be assessed more quickly and easily. Additionally, automated integration of the fluid property modeling into the reservoir modeling and simulation framework allows the compositional gradients produced by the fluid property modeler (particularly asphaltene concentration gradients) to be combined with other data, such as geologic data and other petrophysical data, which allows for more accurate assessment of reservoir compartmentalization.