Systems, methods, and apparatus are described that provide for communicating coexistence messages over a multi-drop serial bus. A method performed at a device coupled to a serial bus includes receiving first coexistence information directed to a first device coupled to the serial bus, generating a first coexistence message representative of the first coexistence information, converting the first coexistence message to obtain a first datagram including the first coexistence information, and transmitting the first datagram to the first device over the serial bus. The first coexistence message may be configured for communication through a point-to-point data link. The first datagram may be configured according to a first protocol associated with the serial bus.