Invention Grant
![2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use](/docs/US/2020-02-04/US10550117B2/abs.jpg.600x600.jpg)
- Patent Title: 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
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Application No.: US16221274Application Date: 2018-12-14
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Publication No.: US10550117B2Publication Date: 2020-02-04
- Inventor: James John Crawford , Aleksandr Kolesnikov , Jianwen A. Feng
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Kevin M Clark
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D417/10 ; A61P27/14 ; A61P37/06 ; A61P17/00 ; A61P19/02 ; A61P1/00 ; A61P11/00
![2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use](/abs-image/US/2020/02/04/US10550117B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to compounds of formula (I): wherein Q, A1, A2, A3, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
Public/Granted literature
- US20190119274A1 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE Public/Granted day:2019-04-25
Information query
