Invention Grant
- Patent Title: Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
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Application No.: US16409323Application Date: 2019-05-10
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Publication No.: US10556914B2Publication Date: 2020-02-11
- Inventor: Jürgen Dinges , Achim Moeller , Michael Ochse , Martin Schmidt , Michael Schulz , Sean Turner , Elizabeth Louise Van Der Kam , Anil Vasudevan
- Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
- Applicant Address: US IL North Chicago DE Wiesbaden
- Assignee: ABBVIE INC.,ABBVIE DEUTSCHLAND GMBH & CO. KG
- Current Assignee: ABBVIE INC.,ABBVIE DEUTSCHLAND GMBH & CO. KG
- Current Assignee Address: US IL North Chicago DE Wiesbaden
- Agency: Neal, Gerber & Eisenberg LLP
- Priority: WOPCT/CN2015/089614 20150915; EP15193907 20151110
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D513/04 ; A61K31/4985

Abstract:
Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
Public/Granted literature
- US20190367531A1 SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE Public/Granted day:2019-12-05
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