-
公开(公告)号：US20240262901A1
公开(公告)日：2024-08-08
申请号：US18638307
申请日：2024-04-17
IPC分类号： C07K16/18 , A61K39/00 , C07K16/28 , G01N33/566
CPC分类号： C07K16/18 , C07K16/28 , G01N33/566 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.
-
公开(公告)号：US20230174645A1
公开(公告)日：2023-06-08
申请号：US17924672
申请日：2021-05-13
发明人： Maria Beconi , John Quisel , Brian MacDonald , Steven Robinette , Bernhard Mueller , Andreas Popp , Jennifer M. Perez
CPC分类号： C07K16/28 , A61P35/00 , C07K2317/565 , C07K2317/24
摘要： Aspects of the application provide anti-hemojuvelin antibodies and methods of using the same in treating myelofibrosis and/or conditions associated with myelofibrosis.
-
3.发明申请公开(公告)号：US20230019186A1
公开(公告)日：2023-01-19
申请号：US17651187
申请日：2022-02-15
发明人： John Hayslip , Leanne M. Holes , Sven Mensing , Silpa Nuthalapati
IPC分类号： A61K31/5377 , A61P35/00 , A61K31/52
摘要： The invention described herein relates to methods for treating a human subject with myelofibrosis or an MPN-related disorder, comprising administering navitoclax to the subject optionally in combination with ruxolitinib.
-
公开(公告)号：US20220259226A1
公开(公告)日：2022-08-18
申请号：US17660355
申请日：2022-04-22
发明人： Wilfried Braje , George Doherty , Katja Jantos , Cheng Ji , Andrew Judd , Aaron Kunzer , Anthony Mastracchio , Xiaohong Song , Andrew Souers , Gerard Sullivan , Zhi-Fu Tao , Chunqiu Lai , Jesse Teske , Michael Wendt , Patrick Brady , Xilu Wang , Thomas Penning , Yujia Dai , Jane Gong , Roberto Risi , Yiyun Yu , Guidong Zhu
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16 , A61K31/519 , C07D491/16 , C07D498/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
-
公开(公告)号：US20220017607A1
公开(公告)日：2022-01-20
申请号：US17182095
申请日：2021-02-22
发明人： Heinz HILLEN , Stefan BARGHORN , Boris LABKOVSKY , Ulrich EBERT , Andreas STRIEBINGER , Patrick KELLER
IPC分类号： C07K16/18 , A61K39/395 , G01N33/577 , G01N33/68
摘要： The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment, and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
-
公开(公告)号：US20210155681A1
公开(公告)日：2021-05-27
申请号：US17034454
申请日：2020-09-28
IPC分类号： C07K16/18 , G01N33/566 , C07K16/28
摘要： Provided herein are methods of using the antibodies that bind to RGMc to treat and diagnose iron-related disorders.
-
公开(公告)号：US20210147381A1
公开(公告)日：2021-05-20
申请号：US16630813
申请日：2018-07-16
发明人： Wilhelm AMBERG , Hervé GENESTE , Wilfried HORNBERGER , Udo LANGE , Mario MEZLER , Michael OCHSE , Frank OELLIEN , Sean C. TURNER , Jeroen VAN BERGEIJK , Elizabeth VAN DER KAM
IPC分类号： C07D401/06 , C07D217/02 , C07D409/06
摘要： The invention relates to 1,2,3,4-substituted quinoline compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
-
公开(公告)号：US10538581B2
公开(公告)日：2020-01-21
申请号：US15290699
申请日：2016-10-11
发明人： Stefan Barghorn , Heinz Hillen , Boris Labkovsky , Andreas R. Striebinger , Patrick Keller , Ulrich Ebert
摘要： Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.
-
公开(公告)号：US20200010480A1
公开(公告)日：2020-01-09
申请号：US16575114
申请日：2019-09-18
发明人： Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
IPC分类号： C07D498/18 , A61P35/00 , C07D519/00 , C07D495/18 , C07D495/16
摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
-
公开(公告)号：US20190071443A1
公开(公告)日：2019-03-07
申请号：US16179050
申请日：2018-11-02
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： C07D471/06 , C07D487/16 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
-
-
-
-
-
-
-
-
-
搜索结果
280 条记录 (耗时 0.05 秒)
