- 专利标题： Near-IR light-cleavable conjugates and conjugate precursors
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申请号： US16323747申请日： 2017-08-07
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公开(公告)号： US10561729B2公开(公告)日： 2020-02-18
- 发明人: Martin John Schnermann , Roger Rauhauser Nani , Alexander Patrick Gorka
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Klarquist Sparkman, LLP
- 国际申请： PCT/US2017/045694 WO 20170807
- 国际公布： WO2018/031448 WO 20180215
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61K31/4545 ; C07D209/10 ; A61K41/00 ; A61P35/00 ; A61K47/54 ; A61K47/68
摘要：
Embodiments of near-infrared light-cleavable heptamethine cyanine-based conjugates, particularly targeting agent-drug conjugates, according to Formula I and conjugate precursors are disclosed. The disclosed targeting agent-drug conjugates are useful for targeted delivery and release of a drug. Methods of making and using the conjugates and precursors also are disclosed.
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