Invention Grant
- Patent Title: In situ nucleic acid sequencing of expanded biological samples
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Application No.: US16110150Application Date: 2018-08-23
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Publication No.: US10563257B2Publication Date: 2020-02-18
- Inventor: Edward Stuart Boyden , Fei Chen , Shahar Alon , George Church , Paul Warren Tillberg , Adam Henry Marblestone , Evan R. Daugharthy
- Applicant: Massachusetts Institute of Technology , President and Fellows of Harvard College
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee: Massachusetts Institute of Technology,President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph Zucchero; Carolyn Elmore
- Main IPC: C12Q1/6874
- IPC: C12Q1/6874 ; C12Q1/6806
Abstract:
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids as well as new methods for fluorescent in situ sequencing (FISSEQ) in a new process referred to herein as “expansion sequencing” (ExSEQ).
Public/Granted literature
- US20190055597A1 In Situ Nucleic Acid Sequencing of Expanded Biological Samples Public/Granted day:2019-02-21
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