A system and associated method receives, by a database coupled to a communication network, patient medical data from multiple data sources including data retrieved from implantable medical devices implanted in patients. A processor accesses the database to generate a dataset from the medical data having at least one data characteristic matching a corresponding data characteristic of a patient group of at least one patient. At least one subset of the dataset is identified that had a therapy intervention subsequent to a time point that the subset had the matching data characteristic(s). An outcome of the subset is determined and a predictive outcome for the patient group is produced based on the outcome of at least one subset.