A product distribution control system for an agricultural system includes a controller having a memory and a processor. The controller is configured to receive a first signal indicative of a prescription map. The controller is further configured to determine a first parameter associated with operation of an air cart of the agricultural system based at least in part on the prescription map. The controller is further configured to determine at least one of a second parameter associated with operation of a work vehicle of the agricultural system based at least in part on the prescription map, and a third parameter associated with an implement of the agricultural system based at least in part on the prescription map, wherein the implement includes one or more row units. The controller is further configured to output, in response to determining the first parameter, a second signal indicative of an instruction to control a first element of the air cart based at least in part on the first parameter, output, in response to determining the second parameter, a third signal indicative of an instruction to control a second element of the work vehicle based at least in part on the second parameter, and output, in response to determining the third parameter, a fourth signal indicative of an instruction to control a third element of the implement based at least in part on the third parameter.