Invention Grant
- Patent Title: Patch
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Application No.: US15454066Application Date: 2017-03-09
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Publication No.: US10583121B2Publication Date: 2020-03-10
- Inventor: Masayuki Suzuki , Hiroaki Okutsu , Takashi Yasukochi , Yasunori Takada
- Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
- Applicant Address: JP Tosu-shi
- Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
- Current Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
- Current Assignee Address: JP Tosu-shi
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2012-165793 20120726; JP2013-078583 20130404
- Main IPC: A61K31/407
- IPC: A61K31/407 ; A61K47/10 ; A61K47/06 ; A61K9/70 ; A61K47/12 ; A61K47/14 ; A61M37/00 ; A61K31/55

Abstract:
A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.
Public/Granted literature
- US20170172981A1 PATCH Public/Granted day:2017-06-22
Information query
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