公开(公告)号：US20230093050A1

公开(公告)日：2023-03-23

申请号：US17798412

申请日：2021-02-04

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Kentaro NAKASHIMA ,  Kento ICHINOHE ,  Keiichiro TSURUSHIMA ,  Takaaki YOSHINAGA

IPC分类号： C09J133/02 ,  C09J11/06 ,  C09J11/08 ,  C09J7/30

摘要： A method for producing an adhesive layer composition for producing a cooling sheet including a backing layer, an adhesive layer, and a liner layer, the method comprising the step of:
mixing a composition to be mixed containing water, an alum, sodium edetate, a polyacrylic acid, and a neutralized polyacrylic acid such that a mixing temperature becomes 5 to 23° C., to obtain an adhesive layer composition, wherein
in the composition to be mixed,
a content of the water is 69 to 938.24% by mass relative to a total mass of the composition to be mixed,
a content of the alum is 0.18 to 0.42% by mass relative to the total mass of the composition to be mixed,
a content of the sodium edetate is 0.08 to 0.18% by mass relative to the total mass of the composition to be mixed, and
a mass ratio between the content of the alum and the content of the sodium edetate (the content of the alum:the content of the sodium edetate) is 1:1 to 5.25:1.

公开(公告)号：US20220265567A1

公开(公告)日：2022-08-25

申请号：US17184797

申请日：2021-02-25

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Hiroyuki SATO ,  Hirochika TAKANO

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/196 ,  A61K47/12

摘要： Disclosed is a method for treating osteoarthritis comprising a step of administering a patch to a patient. The patch comprises a backing layer and an adhesive layer laminated on the backing layer, the adhesive layer comprises an adhesive base, diclofenac sodium, dimethyl sulfoxide, and an organic acid, and a content of the organic acid is 6 mass % to 8 mass % with respect to a total mass of the adhesive layer. The patch is applied to an affected part once a day, and a dose of diclofenac sodium per administration is 70 mg to 150 mg.

公开(公告)号：US11364207B2

公开(公告)日：2022-06-21

申请号：US16483511

申请日：2018-02-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Hideaki Ohashi ,  Takito Shima ,  Kenji Ishigaki ,  Yasunari Michinaka

IPC分类号： A61K9/70 ,  A61K31/4045 ,  A61K47/02

摘要： A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.

公开(公告)号：US20220142940A1

公开(公告)日：2022-05-12

申请号：US17433289

申请日：2020-02-21

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Naoto KAMAKURA ,  Akio TAKEUCHI ,  Hisakazu KURITA

IPC分类号： A61K9/70 ,  A61K47/20

摘要： The present invention provides a transdermal patch comprising an adhesive layer on a backing, wherein the adhesive layer comprises a drug, DMSO, and an adhesive base, and the adhesive base comprises a styrene-based thermoplastic elastomer having a triblock content of 35% to 65%.

公开(公告)号：US11246830B2

公开(公告)日：2022-02-15

申请号：US16975161

申请日：2019-02-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Shinya Matsumura ,  Toshihiro Nakanishi ,  Yasuhisa Kose

IPC分类号： A61K9/06 ,  A61K9/107 ,  A61K31/196 ,  A61K47/32 ,  A61K47/38 ,  A61K47/10 ,  A61K47/44

摘要： The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.

公开(公告)号：US11202764B2

公开(公告)日：2021-12-21

申请号：US16605268

申请日：2018-04-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Kazuya Kominami ,  Takito Shima ,  Naoyuki Uchida ,  Naoko Fujita ,  Shigeo Suzuki ,  Terumitsu Kaiho

IPC分类号： A61K9/70 ,  A61K47/12 ,  A61P25/04 ,  A61K31/485

摘要： A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：US11123305B2

公开(公告)日：2021-09-21

申请号：US16008704

申请日：2018-06-14

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K31/407

摘要： In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US20210244925A1

公开(公告)日：2021-08-12

申请号：US16973553

申请日：2019-07-11

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Eisuke HATANAKA ,  Kazuki KURIYAMA ,  Naoki YAMAMOTO

IPC分类号： A61M37/00

摘要： A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.

公开(公告)号：US11020356B2

公开(公告)日：2021-06-01

申请号：US16474213

申请日：2017-12-26

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC分类号： A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

摘要： The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US10828480B2

公开(公告)日：2020-11-10

申请号：US15756234

申请日：2016-08-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Shinpei Nishimura ,  Seiji Tokumoto ,  Masafumi Ono

IPC分类号： A61M37/00

摘要： An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.