A packet forwarding method, device, and system for use in non-volatile memory express (NVMe) over fabric. According to the method, a first packet sent by a control device is received, and an input/output command or a management command that complies with the NVMe protocol and that is included in the first packet is obtained; a second packet is generated according to the input/output command or the management command, where the input/output command or the management command complies with the NVMe protocol and is included in the first packet, and the second packet is a packet for executing the input/output command or the management command; a network port for forwarding the second packet is selected according to an identity of a target non-volatile memory; and the second packet is encapsulated into a packet that meets an NVMe over fabric forwarding requirement, and the encapsulated second packet is sent by using the selected network port.