Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously, for example, by initializing a sensor, acquiring sensor data, using the sensor, to measure an analyte level in the host's body over a first interval based on a first elapsed time since the sensor was implanted, determining whether the sensor has been previously used in a previous sensor session or the sensor is a new sensor, and upon determining the sensor is a new sensor, adjusting the acquired sensor data to compensate for sensor drift of the new sensor by applying a first set of time-dependent algorithmic functions to the sensor data associated with the first interval.