Methods and systems for segmenting structures in medical images are provided. The methods and systems drive a plurality of transducer element, and collect receive signals from the transducer array at a receive beamformer to form beam summed signals. The methods and systems generate a first ultrasound image of a region of interest (ROI) having tissue elements and blood elements, and generate a second ultrasound image of the ROI having tissue elements and blood elements. The tissue elements of the first ultrasound image having a higher intensity than the blood elements. The blood elements of the second ultrasound image having a higher intensity than the tissue elements. The methods and systems further perform segmentation by simultaneously applying edge detection on the first and second ultrasound images for the ROI.