Invention Grant
- Patent Title: Potent and selective inhibitors of monoamine transporters; method of making; and use thereof
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Application No.: US15830244Application Date: 2017-12-04
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Publication No.: US10590074B2Publication Date: 2020-03-17
- Inventor: Amy Hauck Newman , Oluyomi M. Okunola-Bakare , Jianjing Cao
- Applicant: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health
- Applicant Address: US MD Bethesda
- Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US MD Bethesda
- Agency: Cantor Colburn LLP
- Main IPC: C07C323/60
- IPC: C07C323/60 ; A61K45/06 ; A61K31/135 ; C07C317/44 ; C07C317/28 ; C07C323/25 ; C07D295/08 ; C07D295/088 ; C07D295/108 ; C07D295/185
Abstract:
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
Public/Granted literature
- US20180093947A1 POTENT AND SELECTIVE INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF Public/Granted day:2018-04-05
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