- 专利标题： Dimer impurities of Apixaban and method to remove them
-
申请号： US16456714申请日： 2019-06-28
-
公开(公告)号： US10590133B2公开(公告)日： 2020-03-17
- 发明人: Elena Brasola , Filippo Tomasi , Loris Peruzzi
- 申请人： F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
- 申请人地址： IT Montecchio Maggiore (VI)
- 专利权人： F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
- 当前专利权人： F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A.
- 当前专利权人地址： IT Montecchio Maggiore (VI)
- 代理机构： Lucas & Mercanti, LLP
- 优先权： EP15177517 20150720
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; B01D11/02 ; C07B63/00 ; C07D413/04 ; C07D413/14 ; G01N30/36 ; G01N30/72 ; G01N30/02
摘要：
Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
公开/授权文献
- US20190367509A1 DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM 公开/授权日：2019-12-05
信息查询
