公开(公告)号：US12123856B2

公开(公告)日：2024-10-22

申请号：US17659772

申请日：2022-04-19

申请人： Roche Diagnostics Operations, Inc.

发明人： Andreas Leinenbach ,  Aart Pieter van Doorn

IPC分类号： G01N30/02 ,  G01N30/36

CPC分类号： G01N30/36 ,  G01N2030/027

摘要： A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

公开(公告)号：US12000808B2

公开(公告)日：2024-06-04

申请号：US17348531

申请日：2021-06-15

申请人： Agilent Technologies, Inc.

发明人： Clemens Plachetka ,  Konstantin Shoykhet ,  Tony Ziegler ,  Joachim-Richard Wagner ,  Manfred Berndt

IPC分类号： B01D15/14 ,  G01N30/02 ,  G01N30/20 ,  G01N30/32 ,  G01N30/36

CPC分类号： G01N30/36 ,  B01D15/14 ,  G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201

摘要： A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.

公开(公告)号：US11959894B2

公开(公告)日：2024-04-16

申请号：US16971216

申请日：2019-02-22

申请人： SILCOTEK CORP.

发明人： Jesse Bischof ,  Lucas D. Patterson ,  Gary Barone ,  Min Yuan ,  David A. Smith

IPC分类号： G01N30/56 ,  B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  B01D15/38 ,  G01N30/30 ,  G01N30/36 ,  B01J20/32 ,  G01N30/02 ,  G01N30/60

CPC分类号： G01N30/56 ,  B01D15/161 ,  B01D15/163 ,  B01D15/166 ,  B01D15/206 ,  B01D15/22 ,  B01D15/3828 ,  G01N30/30 ,  G01N30/36 ,  B01J20/3265 ,  G01N2030/027 ,  G01N2030/567 ,  G01N30/60

摘要： LC techniques are disclosed. The LC technique includes providing a liquid chromatography system having a coated metallic fluid-contacting element, and transporting a fluid to contact the coated metallic fluid contacting element. Conditions for the transporting of the fluid are selected from the group consisting of the temperature of the fluid being greater than 150 degree Celsius, pressure urging the fluid being greater than 60 MPa, the fluid having a protein-containing analyte incompatible with one of titanium and polyether ether ketone, the fluid having a chelating agent incompatible with the one or both of the titanium or the polyether ether ketone.

公开(公告)号：US20230077255A1

公开(公告)日：2023-03-09

申请号：US17718162

申请日：2022-04-11

申请人： Genentech, Inc.

发明人： Mary MONTTI ,  Richard L. Beardsley ,  Michael S. Chinn

IPC分类号： G01N30/96 ,  G01N30/36 ,  B01D15/38

摘要： The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

公开(公告)号：US11371968B2

公开(公告)日：2022-06-28

申请号：US16917908

申请日：2020-07-01

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Daniel Thielsch ,  Dominik Ruf

IPC分类号： G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

摘要： A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20210382019A1

公开(公告)日：2021-12-09

申请号：US17411488

申请日：2021-08-25

申请人： Valco Instruments Company, L.P.

发明人： Stanley D. Stearns ,  Ales Plistil

IPC分类号： G01N30/36 ,  G01N30/32 ,  G01N30/20

摘要： Systems for use with liquid chromatography for provision of continuous flow or gradient flow in connection with two pumps providing mobile phase to a valve.

公开(公告)号：US11119076B2

公开(公告)日：2021-09-14

申请号：US16281965

申请日：2019-02-21

申请人： Valco Instruments Company, L.P.

发明人： Stanley D. Stearns ,  Ales Plistil

IPC分类号： G01N30/20 ,  G01N30/32 ,  G01N30/36

摘要： Systems for use with liquid chromatography for provision of continuous flow or gradient flow in connection with two pumps providing mobile phase to a valve.

公开(公告)号：US11105779B2

公开(公告)日：2021-08-31

申请号：US16269559

申请日：2019-02-06

申请人： Longyuan Mei ,  Longzhi Mei ,  Longyu Mei

发明人： Longyuan Mei ,  Longzhi Mei ,  Longyu Mei

IPC分类号： G01N30/36 ,  G01N30/32

摘要： A pressure system for liquid chromatography allows multiple fluid lines to be driven in parallel by a single pump. A fluid pressure medium supply provides fluid pressure to the system. The fluid pressure medium supply is connected to a plurality of fluid transfer pipes, each with a flow limiter. The fluid pressure medium supply is configured to provided more flow than the flow limiters combined, and excess flow is either diverted with a pressure limiter or reduced with a pressure adjuster, or both. Further layers of pressure and flow control may be added with additional pressure limiters and/or pressure adjusters and flow limiters connected together. In some cases, multiple lines containing different fluids may be driven by the same pressure source through the use of flexible fluid delivery inner containers, each within a rigid container that is pressurized by the pressure source.

公开(公告)号：US20210017970A1

公开(公告)日：2021-01-21

申请号：US17063870

申请日：2020-10-06

申请人： Christoph STROBL

发明人： Christoph STROBL

IPC分类号： F04B11/00 ,  G01N30/36

摘要： A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for.

公开(公告)号：US10816517B2

公开(公告)日：2020-10-27

申请号：US16040734

申请日：2018-07-20

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： Daisuke Takeda ,  Akiyo Kojima

IPC分类号： G01N30/36 ,  G01N30/34 ,  G01N30/88 ,  G01N30/02

摘要： The present invention provides a novel method that is capable of detecting a trifluridine-related substance from a sample containing trifluridine or a salt thereof by high-performance liquid chromatography comprising two steps that are performed under gradient conditions. More specifically, the method is for detecting a trifluridine-related substance, the method comprising the step of subjecting a sample containing trifluridine or a salt thereof to high-performance liquid chromatography using a mobile phase composed of an organic phase and an aqueous phase, wherein the step of high-performance liquid chromatography comprises steps 1 and 2 that satisfy the following requirements: Step 1: the percentage of the organic phase in the entire mobile phase is 1 to 14% by volume; and Step 2: after step 1, elution is performed by applying a gradient of increasing the percentage of the organic phase in the entire mobile phase.