Invention Grant
- Patent Title: Mitochondria-targeting fluorescent potassium+ sensor and method of making the same
-
Application No.: US16314753Application Date: 2017-07-14
-
Publication No.: US10590155B2Publication Date: 2020-03-17
- Inventor: Xiangxing Kong , Yanqing Tian , Fengyu Su , Liqiang Zhang , Deirdre Meldrum
- Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Quarles & Brady LLP
- Agent Jessica L. Lewis
- International Application: PCT/US2017/042174 WO 20170714
- International Announcement: WO2018/013948 WO 20180118
- Main IPC: C07F9/6596
- IPC: C07F9/6596 ; G01N33/50 ; G01N33/58 ; G01N33/68
Abstract:
Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.
Public/Granted literature
- US20190153005A1 MITOCHONDRIA-TARGETING FLUORESCENT POTASSIUM+ SENSOR AND METHOD OF MAKING THE SAME Public/Granted day:2019-05-23
Information query
