Invention Grant
- Patent Title: Method of producing proteins in filamentous fungi with decreased CLR1 activity
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Application No.: US15779646Application Date: 2016-12-02
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Publication No.: US10597429B2Publication Date: 2020-03-24
- Inventor: Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
- Applicant: BASF SE
- Applicant Address: DE Ludwigshafen am Rhein
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen am Rhein
- Agency: Armstrong Teasdale LLP
- Priority: EP15197493 20151202
- International Application: PCT/EP2016/079527 WO 20161202
- International Announcement: WO2017/093451 WO 20170608
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12P21/02 ; C12Q1/34 ; C12N1/14 ; C12N15/01 ; C12N15/80 ; C12P19/14 ; C07K14/37 ; C12N9/42
Abstract:
The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.
Public/Granted literature
- US20180354999A1 METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR1 ACTIVITY Public/Granted day:2018-12-13
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