Invention Grant
- Patent Title: Device for nucleic acid sequencing
-
Application No.: US15394371Application Date: 2016-12-29
-
Publication No.: US10597716B2Publication Date: 2020-03-24
- Inventor: Alessandro Paolo Bramanti , Marco Angelo Bianchessi
- Applicant: STMICROELECTRONICS S.R.L.
- Applicant Address: IT Agrate Brianza
- Assignee: STMICROELECTRONICS S.R.L.
- Current Assignee: STMICROELECTRONICS S.R.L.
- Current Assignee Address: IT Agrate Brianza
- Agency: Seed IP Law Group LLP
- Priority: IT102016000067063 20160628
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/6874 ; C12Q1/6869

Abstract:
A method for sequencing a nucleic acid strand, comprising the steps of: providing a solution containing truncated strands having lengths different from one another terminating with a respective dideoxynucleotide from among ddATP, ddTTP, ddGTP, and ddCTP; functionalizing first masses by a donor molecule and second masses by an acceptor molecule such as to generate a light emission when they come into mutual contact; coupling a first mass to a first end of each truncated strand; coupling the second masses to a respective terminal dideoxynucleotide of each strand; applying an AC electrical field having variable frequencies that are such as to generate, on each second mass, a net movement directed towards the first mass; acquiring a plurality of light radiations for each frequency value; and associating each light radiation acquired to a respective dideoxynucleotide and, thus, to a respective nucleotide base.
Public/Granted literature
- US20170369943A1 METHOD AND DEVICE FOR NUCLEIC ACID SEQUENCING Public/Granted day:2017-12-28
Information query