Invention Grant
- Patent Title: Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity
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Application No.: US15563501Application Date: 2016-04-01
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Publication No.: US10647678B2Publication Date: 2020-05-12
- Inventor: Keith Jones , Matthew Cheeseman , Nicola Chessum , Elisa Pasqua , Lindsay Evans , Michael Tucker , Birgit Wilding , Ngai Yi Mok
- Applicant: Cancer Research Technology Limited
- Applicant Address: GB London
- Assignee: Cancer Research Technology Limited
- Current Assignee: Cancer Research Technology Limited
- Current Assignee Address: GB London
- Agency: Foley Hoag LLP
- Agent David P. Halstead; Lucas P. Watkins
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3ab413dd
- International Application: PCT/GB2016/050938 WO 20160401
- International Announcement: WO2016/156872 WO 20161006
- Main IPC: C07D215/48
- IPC: C07D215/48 ; C07D405/12
Abstract:
The present invention relates to compounds of formula I wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
Public/Granted literature
- US20180093955A1 QUINOLINE DERIVATIVES AS INHIBITORS OF HEAT SHOCK FACTOR 1 PATHWAY ACTIVITY Public/Granted day:2018-04-05
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