公开(公告)号：US10647678B2

公开(公告)日：2020-05-12

申请号：US15563501

申请日：2016-04-01

Applicant: Cancer Research Technology Limited

Inventor： Keith Jones ,  Matthew Cheeseman ,  Nicola Chessum ,  Elisa Pasqua ,  Lindsay Evans ,  Michael Tucker ,  Birgit Wilding ,  Ngai Yi Mok

IPC: C07D215/48 ,  C07D405/12

Abstract: The present invention relates to compounds of formula I wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.