- 专利标题： Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from epsilon-amino lysine moieties
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申请号： US16387992申请日： 2019-04-18
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公开(公告)号： US10648013B2公开(公告)日： 2020-05-12
- 发明人: Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
- 申请人： Enzo Life Sciences, Inc.
- 申请人地址： US NY Farmingdale
- 专利权人： Enzo Life Sciences, Inc.
- 当前专利权人： Enzo Life Sciences, Inc.
- 当前专利权人地址： US NY Farmingdale
- 代理商 Paul Diamond, Esq.
- 主分类号： G01N33/573
- IPC分类号： G01N33/573 ; C12Q1/37 ; C07D493/10 ; C12Q1/34 ; C07D311/16
摘要：
Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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