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公开(公告)号：US10920265B2
公开(公告)日：2021-02-16
申请号：US16833816
申请日：2020-03-30
IPC分类号： C12Q1/34 , C07D311/16 , C07D493/10
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US10648013B2
公开(公告)日：2020-05-12
申请号：US16387992
申请日：2019-04-18
IPC分类号： G01N33/573 , C12Q1/37 , C07D493/10 , C12Q1/34 , C07D311/16
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US10308974B2
公开(公告)日：2019-06-04
申请号：US15944336
申请日：2018-04-03
IPC分类号： C07D311/16 , C12Q1/34 , C07D493/10
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US20180223328A1
公开(公告)日：2018-08-09
申请号：US15944336
申请日：2018-04-03
IPC分类号： C12Q1/34 , C07D493/10 , C07D311/16
CPC分类号： C12Q1/34 , C07D311/16 , C07D493/10 , C12Y305/01098 , G01N2333/98
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US09963734B2
公开(公告)日：2018-05-08
申请号：US15464966
申请日：2017-03-21
IPC分类号： C07D311/96 , C12Q1/34 , C07D493/10 , C07D311/16
CPC分类号： C12Q1/34 , C07D311/16 , C07D493/10 , C12Y305/01098 , G01N2333/98
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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公开(公告)号：US20170198333A1
公开(公告)日：2017-07-13
申请号：US15464966
申请日：2017-03-21
IPC分类号： C12Q1/34 , C07D311/16 , C07D493/10
CPC分类号： C12Q1/34 , C07D311/16 , C07D493/10 , C12Y305/01098 , G01N2333/98
摘要： Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
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