Some demonstrative embodiments include apparatus, system and method of communicating a Single Carrier (SC) transmission. For example, an apparatus of a SC Physical Layer (PHY) transmitter may include a spatial stream parser to distribute encoded bits of a Physical Layer Convergence Procedure (PLCP) Service Data Unit (PSDU) to a plurality of spatial streams; a plurality of constellation mappers to map encoded bits of the plurality of spatial streams into a respective plurality of streams of constellation symbols according to a constellation scheme; a Space Time Block Code (STBC) encoder to encode the plurality of streams of constellation symbols into SC symbol blocks over a plurality of space-time streams; and a transmit beamforming module to map the plurality of space-time streams to a plurality of transmit chains.