Invention Grant
- Patent Title: Inhibitors of myocardin-related transcription factor and serum response factor (MRTF/SRF)-mediated gene transcription and methods for use of the same
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Application No.: US14934769Application Date: 2015-11-06
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Publication No.: US10662183B2Publication Date: 2020-05-26
- Inventor: Scott D. Larsen , Richard Neubig , Andrew Haak , Kim Hutchings , Walajapet Rajeswaran , Dinesh Khanna , Erika Mathes Lisabeth
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
- Applicant Address: US MI Ann Arbor US MI East Lansing
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
- Current Assignee Address: US MI Ann Arbor US MI East Lansing
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: C07D211/06
- IPC: C07D211/06 ; C07D211/60 ; C07D417/14 ; C07D405/10 ; C07D409/10 ; C07D405/14 ; C07D401/10 ; C07D401/06 ; C07D417/06 ; C07D413/14 ; C07D417/10 ; C07D413/06 ; C07D405/06
Abstract:
Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
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