- 专利标题： Antibody drug conjugates (ADC) that bind to 158P1D7 proteins
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申请号： US15895996申请日： 2018-02-13
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公开(公告)号： US10669348B2公开(公告)日： 2020-06-02
- 发明人: Robert Kendall Morrison , Zili An , Karen Jane Meyrick Morrison , Josh Snyder , Xiao-Chi Jia
- 申请人： AGENSYS, INC. , SEATTLE GENETICS, INC.
- 申请人地址： US CA Santa Monica US WA Bothell
- 专利权人： AGENSYS, INC.,SEATTLE GENETICS, INC.
- 当前专利权人： AGENSYS, INC.,SEATTLE GENETICS, INC.
- 当前专利权人地址： US CA Santa Monica US WA Bothell
- 代理机构： Jones Day
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/30 ; C07K16/18 ; A61K45/06 ; A61K47/68 ; A61P35/00
摘要：
Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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