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公开(公告)号：USRE47103E1
公开(公告)日：2018-10-30
申请号：US15448507
申请日：2017-03-02
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US10669348B2
公开(公告)日：2020-06-02
申请号：US15895996
申请日：2018-02-13
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09926376B2
公开(公告)日：2018-03-27
申请号：US15085877
申请日：2016-03-30
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US08968742B2
公开(公告)日：2015-03-03
申请号：US13975214
申请日：2013-08-23
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合158P1D7蛋白的抗体药物偶联物（ADC）及其变体。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US11633500B2
公开(公告)日：2023-04-25
申请号：US16852148
申请日：2020-04-17
申请人： AGENSYS, INC.
发明人： Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
摘要： Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09925273B2
公开(公告)日：2018-03-27
申请号：US14447209
申请日：2014-07-30
申请人： AGENSYS, INC.
发明人： Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
IPC分类号： A61K39/395 , A61K47/48 , A61K45/06
CPC分类号： A61K47/6851 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849
摘要： Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US11634503B2
公开(公告)日：2023-04-25
申请号：US16866408
申请日：2020-05-04
申请人： AGENSYS, INC. , SEAGEN INC.
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US09974865B2
公开(公告)日：2018-05-22
申请号：US15065707
申请日：2016-03-09
申请人： AGENSYS, INC.
发明人： Christine Lowe , Nandini Rudra-Ganguly , Faisal Hayat Malik , Sung Ju Moon , Josh Snyder , Hector Avina , Cyrus Virata , Linnette Capo , Gao Liu
CPC分类号： A61K47/6803 , A61K45/06 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732
摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20160272716A1
公开(公告)日：2016-09-22
申请号：US15065707
申请日：2016-03-09
申请人： AGENSYS, INC.
发明人： Christine Lowe , Nandini Rudra-Ganguly , Faisal Hayat Malik , Sung Ju Moon , Josh Snyder , Hector Avina , Cyrus Virata , Linnette Capo , Gao Liu
CPC分类号： A61K47/6803 , A61K45/06 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732
摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合FLT3蛋白及其变体的抗体药物偶联物（ADC）。 FLT3在正常成人组织中表现出明显且有限的表达模式，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US10751422B2
公开(公告)日：2020-08-25
申请号：US15556587
申请日：2016-03-09
申请人： AGENSYS, INC.
发明人： Nandini Rudra-Ganguly , Christine Lowe , Faisal Hayat Malik , Sung Ju Moon , Josh Snyder , Hector Avina , Cyrus Virata , Linnette Capo , Gao Liu
摘要： Antibody drug conjugates (ADC's) that bind to FLT3 protein and variants thereof are described herein. FLT3 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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