- 专利标题： Kappa opioid receptor antagonists and products and methods related thereto
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申请号： US15924119申请日： 2018-03-16
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公开(公告)号： US10676469B2公开(公告)日： 2020-06-09
- 发明人: Edward Roberts , Miguel A. Guerrero , Mariangela Urbano , Hugh Rosen , Robert M. Jones , Candace Mae Laxamana , Xianrui Zhao , Eric Douglas Turtle
- 申请人： The Scripps Research Institute , BlackThorn Therapeutics, Inc.
- 申请人地址： US CA San Francisco US CA La Jolla
- 专利权人： BLACKTHORN THERAPEUTICS, INC.,THE SCRIPPS RESEARCH INSTITUTE
- 当前专利权人： BLACKTHORN THERAPEUTICS, INC.,THE SCRIPPS RESEARCH INSTITUTE
- 当前专利权人地址： US CA San Francisco US CA La Jolla
- 代理机构： Seed IP Law Group LLP
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; A61P25/00 ; A61P25/06
摘要：
Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R1, R2, R4, R5 R6, R7, R8 and R11 are as defined herein.
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