Invention Grant
- Patent Title: Antibodies conjugatable by transglutaminase and conjugates made therefrom
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Application No.: US15555594Application Date: 2016-03-01
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Publication No.: US10676773B2Publication Date: 2020-06-09
- Inventor: Chetana Rao-Naik , Shrikant Deshpande
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- International Application: PCT/US2016/020192 WO 20160301
- International Announcement: WO2016/144608 WO 20160915
- Main IPC: C12P21/02
- IPC: C12P21/02 ; A61K47/68 ; C07K16/28 ; C07K16/30
Abstract:
An antibody has at a heavy chain thereof a C-terminal extension that includes at least one glutamine that is a substrate for transglutaminase, enabling the transglutaminase-mediated preparation antibody-drug conjugates using such antibody.
Public/Granted literature
- US20180037921A1 ANTIBODIES CONJUGATABLE BY TRANSGLUTAMINASE AND CONJUGATES MADE THEREFROM Public/Granted day:2018-02-08
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