公开(公告)号：US11623965B2

公开(公告)日：2023-04-11

申请号：US16103654

申请日：2018-08-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stanley R. Krystek, Jr. ,  Yong Zhang ,  Gregory D. Vite ,  Arvind Rajpal ,  Chetana Rao-Naik ,  Paul E. Morin ,  Mohan Srinivasan ,  Zheng Lin ,  Virginie Lafont ,  Alla Pritsker

IPC: C07K16/46 ,  A61K39/395 ,  A61K47/60 ,  A61K47/65 ,  C07K16/28 ,  A61P29/00 ,  A61P35/00

Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.

公开(公告)号：US12290570B2

公开(公告)日：2025-05-06

申请号：US17297796

申请日：2019-11-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pavel Strop ,  Chetana Rao-Naik ,  Xiaodi Deng ,  Paul O. Sheppard ,  Patrick G. Holder ,  Sayumi Yamazoe

IPC: A61K47/68 ,  C07K16/18

Abstract: An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.

公开(公告)号：US10676773B2

公开(公告)日：2020-06-09

申请号：US15555594

申请日：2016-03-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Chetana Rao-Naik ,  Shrikant Deshpande

IPC: C12P21/02 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30

Abstract: An antibody has at a heavy chain thereof a C-terminal extension that includes at least one glutamine that is a substrate for transglutaminase, enabling the transglutaminase-mediated preparation antibody-drug conjugates using such antibody.

公开(公告)号：US20190055321A1

公开(公告)日：2019-02-21

申请号：US16103654

申请日：2018-08-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stanley R. Krystek, JR. ,  Yong Zhang ,  Gregory D. Vite ,  Arvind Rajpal ,  Chetana Rao-Naik ,  Paul E. Morin ,  Mohan Srinivasan ,  Zheng Lin ,  Virginie Lafont ,  Alla Pritsker

IPC: C07K16/46

Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.

公开(公告)号：US20230295346A1

公开(公告)日：2023-09-21

申请号：US18180998

申请日：2023-03-09

Applicant: BRISTOL -MYERS SQUIBB COMPANY

Inventor： Stanley R. Krystek, JR. ,  Yong Zhang ,  Gregory D. Vite ,  Arvind Rajpal ,  Chetana Rao-Naik ,  Paul E. Morin ,  Mohan Srinivasan ,  Zheng Lin ,  Virginie Lafont ,  Alla Pritsker

IPC: C07K16/46 ,  A61K39/395 ,  A61K47/60 ,  A61K47/65 ,  C07K16/28

CPC classification number: C07K16/464 ,  A61K39/39533 ,  A61K47/60 ,  A61K47/65 ,  C07K16/2818 ,  C07K16/2878 ,  A61P29/00 ,  C07K2317/24 ,  C07K2317/515 ,  C07K2317/76 ,  C07K2319/50

Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.