An array substrate, a display panel, a display device and a driving method. The array substrate includes: a plurality of first pixel units arranged in an array in a first region; a first gate driving circuit a second gate driving circuit; a plurality of first gate lines connected with the first gate driving circuit; and a plurality of second gate lines connected with the second gate driving circuit. A first portion of the plurality of first pixel units is connected with the plurality of first gate lines, and each first pixel unit in the first portion is connected with one of the plurality of first gate lines; and a second portion of the plurality of first pixel units is connected with the plurality of second gate lines, and each first pixel unit in the second portion is connected with one of the plurality of second gate lines.