Invention Grant
- Patent Title: Dual specific antibodies
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Application No.: US15167030Application Date: 2016-05-27
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Publication No.: US10683348B2Publication Date: 2020-06-16
- Inventor: Germaine Fuh , Chingwei V. Lee , Patrick Koenig
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Clark & Elbing LLP
- Agent Karen L. Elbing
- Main IPC: C07K16/32
- IPC: C07K16/32 ; C07K16/28 ; C07K16/22 ; C07K16/42 ; C07K16/46 ; A61K39/00 ; C07K16/24 ; A61K39/395 ; A61K45/06

Abstract:
The invention provides dual specific antibodies and methods of making and using such antibodies. In general, the dual specific antibodies are generated by identification of a monospecific antibody having light chain variable region VL residues that are electrostatic or hydrophobic and altering the nucleic acid sequence encoding one or more solvent accessible residues in the VH of the antibody either alone or in combination with alteration of the nucleic acid sequence encoding the VL of the antibody. The altered VH and the VL are expressed and dual specific antibodies, or antigen-binding fragments thereof, are selected. Exemplary dual specific antibodies are also provided as well as methods of using the antibodies.
Public/Granted literature
- US20160257744A1 DUAL SPECIFIC ANTIBODIES Public/Granted day:2016-09-08
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