A screen providing a graphical user interface (GUI) for a tissue biopsy system includes a circular area and a plurality of GUI areas of variable size located in the circular area. The plurality of GUI areas includes a first GUI area, a second GUI area, and a third GUI area. The first GUI area is configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by a tissue cutting member. The second GUI area is configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The third GUI area is configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site.