An image sensing device and an image sensing method are provided. The image sensing device includes an image sensing array, multiple first signal converters, and multiple first image processing apparatuses. The image sensing array is partitioned into at least two or more first pixel capturing areas, and each of the first pixel capturing areas is compliant with a resolution of an SDTV format. Each of the first signal converters receives an analog image signal from a corresponding first pixel capturing area, converts the analog image signal from an analog format to a digital format to generate a first digital image signal, and converts the first digital image signal from an parallel format to a serial format. Each of the image processing apparatuses is configured to convert the first digital image signal in the serial format of a corresponding first signal converter to a video signal in a specific video format.