Systems, methods, and apparatus are described that enable a device to indicate availability of priority data to be communicated over a half-duplex serial bus without waiting for an ongoing transmission to be completed. In-datagram critical signaling is accommodated without breaking backward compatibility. A method implemented at a transmitting device coupled to a serial bus includes transmitting a data byte over a first line of the serial bus to a receiving device in accordance with a clock signal transmitted by a master device on a second line of the serial device, detecting a first pulse on the first line of the serial bus during a cycle of the clock signal designated for an acknowledgement or negative acknowledgement by the second device, and processing an alert indicated by the first pulse.