Invention Grant
- Patent Title: Macrocyclic lactone compounds and methods for their use
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Application No.: US16154501Application Date: 2018-10-08
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Publication No.: US10695327B2Publication Date: 2020-06-30
- Inventor: John Yan , Xiaoxia Zheng , Vinayak D. Bhat
- Applicant: Elixir Medical Corporation
- Applicant Address: US CA Milpitas
- Assignee: Elixir Medical Corporation
- Current Assignee: Elixir Medical Corporation
- Current Assignee Address: US CA Milpitas
- Agency: Wilson Sonsini Goodrich & Rosati
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K9/00 ; A61K31/436 ; A61K31/439 ; A61K31/4525

Abstract:
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.
Public/Granted literature
- US20190275013A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE Public/Granted day:2019-09-12
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