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    METHODS AND DEVICES FOR DELIVERING IMPLANTABLE PROSTHESES
    1.
    发明申请
    METHODS AND DEVICES FOR DELIVERING IMPLANTABLE PROSTHESES 有权

    公开(公告)号：US20220370097A1

    公开(公告)日：2022-11-24

    申请号：US17568475

    申请日：2022-01-04

    申请人： Elixir Medical Corporation

    发明人： MOTASIM SIRHAN ,  JOHN YAN ,  VINAYAK BHAT ,  JOSEPH PARASCHAC ,  BENJAMYN SERNA

    IPC分类号： A61B17/34 ,  A61B17/00

    摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaptation of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

    METHODS AND DEVICES FOR HEART VALVE REPAIR
    2.
    发明申请
    METHODS AND DEVICES FOR HEART VALVE REPAIR 有权

    公开(公告)号：US20210186722A1

    公开(公告)日：2021-06-24

    申请号：US17195478

    申请日：2021-03-08

    申请人： Elixir Medical Corporation

    发明人： Motasim Sirhan ,  Vinayak Bhat ,  Joseph Paraschac ,  Benjamyn Serna ,  John Yan

    IPC分类号： A61F2/89 ,  A61F2/915 ,  A61F2/90 ,  A61F2/24

    摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

    METHODS AND DEVICES FOR HEART VALVE REPAIR
    3.
    发明申请
    METHODS AND DEVICES FOR HEART VALVE REPAIR 有权

    公开(公告)号：US20210038411A1

    公开(公告)日：2021-02-11

    申请号：US17073052

    申请日：2020-10-16

    申请人： Elixir Medical Corporation

    发明人： Motasim Sirhan ,  Vinayak Bhat ,  Joseph Paraschac ,  Benjamyn Serna ,  John Yan

    IPC分类号： A61F2/89 ,  A61F2/915 ,  A61F2/90

    摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

    Macrocyclic lactone compounds and methods for their use
    5.
    发明授权
    Macrocyclic lactone compounds and methods for their use 有权

    公开(公告)号：US10123996B2

    公开(公告)日：2018-11-13

    申请号：US15181284

    申请日：2016-06-13

    申请人： Elixir Medical Corporation

    发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

    IPC分类号： A61K31/436 ,  A61K45/06 ,  A61K31/365 ,  A61K31/427 ,  A61K9/00

    摘要： A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.