Invention Grant
- Patent Title: Therapeutic compounds and uses thereof
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Application No.: US16198597Application Date: 2018-11-21
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Publication No.: US10696655B2Publication Date: 2020-06-30
- Inventor: Patrick Cyr , Sarah Bronner , F. Anthony Romero , Steven Magnuson , Vickie Hsiao-Wei Tsui , John Wai , Kwong Wah Lai , Fei Wang
- Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
- Applicant Address: US CA South San Francisco US MA Cambridge
- Assignee: GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS, INC.
- Current Assignee: GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS, INC.
- Current Assignee Address: US CA South San Francisco US MA Cambridge
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: C07D223/16
- IPC: C07D223/16 ; C07D243/12 ; C07D243/14 ; C07D267/14 ; C07D403/04 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D413/04 ; C07D417/14 ; C07D401/14 ; C07D413/14 ; C07D471/04 ; C07D487/04 ; C07D413/10 ; A61K31/435 ; A61K31/437 ; A61K31/4375 ; A61K31/496 ; A61K31/4985 ; A61K31/5025 ; A61K31/519 ; A61K31/5377 ; A61K31/5513 ; A61K45/06 ; C07D487/22
Abstract:
The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
Public/Granted literature
- US20190152949A1 THERAPEUTIC COMPOUNDS AND USES THEREOF Public/Granted day:2019-05-23
Information query
