Various embodiments of the present invention relate to a device and a method for setting an area for an interaction of reactive content in an electronic device, wherein an electronic device operating method can comprise the steps of: displaying an image acquired from an external electronic device electrically connected to the electronic device; correcting the image into a top view form; displaying a guide interface of a lattice pattern form such that the image corrected into a top view form is overlapped therewith; selecting at least a partial area of the guide interface; applying spatial coordinates for the at least partial area so as to set an area for an interaction in a sensor of the external electronic device; copying the selected at least partial area and attaching the same to an adjacent other area; and mapping content to the area for an interaction. Other embodiments are possible.