Systems, apparatuses, and methods for maintaining region-based cache directories split between node and memory are disclosed. The system with multiple processing nodes includes cache directories split between the nodes and memory to help manage cache coherency among the nodes' cache subsystems. In order to reduce the number of entries in the cache directories, the cache directories track coherency on a region basis rather than on a cache line basis, wherein a region includes multiple cache lines. Each processing node includes a node-based cache directory to track regions which have at least one cache line cached in any cache subsystem in the node. The node-based cache directory includes a reference count field in each entry to track the aggregate number of cache lines that are cached per region. The memory-based cache directory includes entries for regions which have an entry stored in any node-based cache directory of the system.