A data processing system and a method of runtime configuration of the data processing system are disclosed. The data processing system comprises a plurality of home nodes, and for a data store associated with a slave node in the data processing system, for each home node of the plurality of home nodes a modified size of the data store is determined. The modified size is based on a storage capacity of the data store and at least one additional property of the data processing system. A chosen home node of the plurality of home nodes is selected which satisfies a minimization criterion for the modified size, and the chosen home node is paired with the slave node.