Integrated circuits with digital signal processing (DSP) blocks are provided. A DSP block may include one or more large multiplier circuits. A large multiplier circuit such as an 18×18 multiplier circuit may be used to support two or more smaller multiplication operations such as two 8×8 integer multiplications or two 9×9 integer multiplications. To implement the two 8×8 or 9×9 unsigned/signed multiplications, the 18×18 multiplier may be configured to support two 8×8 multiplications with one shared operand, two 6×6 multiplications without any shared operand, or two 7×7 multiplications without any shared operand. Any potential overlap of partial product terms may be subtracted out using correction logic. The multiplication of the remaining most significant bits can be computed using associated multiplier extension logic and appended to the other least significant bits using merging logic.