Systems and methods for multi-threshold sensing at an audio receiver, and systems and methods for calibrating an audio system to optimize for the specific configuration of the audio system are disclosed herein. In some implementations of a multi-threshold receiver, at least one additional voltage level is selected to trigger latching events within the receiver based on changes of the receiver input (which includes differential signals Vp and Vn) and in turn, to generate internal signals within the multi-threshold receiver, and then logic operations are performed on these internal signals to generate the output of the multi-threshold receiver.